The primary interest of our lab is the relationship between the anatomical and physiological characteristics of interneurons and their functions in cortical networks.
Our working hypothesis is that inhibitory interneurons play a central role in coordinating neuronal activity in circuits of the brain. The diversity of interneurons serves a complex division of labour; the various types provide inhibition at different times and locations and determine when and where information can flow in the circuit.
We focus on the hippocampus, a brain area essential for learning and memory and often affected in neurological and psychiatric disorders of the brain (e.g. epilepsy, Alzheimer disease). Furthermore, with its relatively simple structure, the hippocampus is considered as a model (blueprint) for more complex neocortical circuits.
Our experimental approach involve in vitro electrophysiological recording techniques, morphological and immunocytochemical analysis, and computational modeling.